Season 16(2008)
season - first aired/released 2008-09-02
Talk, Comedy
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Cast
David LettermanSelf - Host
Paul ShafferSelf - Musical Director- Alan KalterSelf - Announcer
Drew BarrymoreSelf - Guest- Rupert JeeSelf
Chris RockSelf - Top 10 Presenter
Jack HannaSelf - Guest
Dolly PartonSelf - Guest
Donald TrumpSelf - Guest- Neko CaseSelf - Musical Guest
Leonard NimoySelf - Top Ten List Presenter
Norm MacdonaldSelf - Guest
John PopperSelf - Musical Guest
Zachary QuintoSelf - Guest- Biff HendersonSelf - Stage Manager, Self
Lou ReedSelf - Musical Guest
Jeremy PivenSelf - Guest
Elizabeth BanksSelf - Guest
Show all 80 cast members
Chris ElliottSelf- Gerard MulliganSelf
Josh BrolinSelf - Guest
Amy SedarisSelf - Guest
Bruce WillisSelf - Top Ten Presenter, Self - Guest
SiaSelf - Musical Guest
Ben HarperSelf - Musical Guest
Paul McCartneySelf - Musical Guest
Graham NashSelf - Musical Guest
Ryan AdamsSelf - Musical Guest
Kim GordonSelf - Musical Guest
Thurston MooreSelf - Musical Guest
Steve ShelleySelf - Musical Guest
Lee RanaldoSelf - Musical Guest
Kathy GriffinSelf - Guest
Steve NashSelf - Guest- Tony MendezSelf
Reese WitherspoonSelf - Guest
Harry Connick Jr.Self - Musical Guest
Jim ParsonsSelf - Guest
BeyoncéSelf - Guest- Care Bears on FireSelf - Musical Guest
Anne HecheSelf - Guest
Ricky GervaisSelf - Guest
Thomas L. FriedmanSelf - Guest
Keira KnightleySelf - Guest
David SanbornSelf - Musical Guest
Alec BaldwinSelf - Guest
Paul MooneySelf - Guest
Maya RudolphSelf - Guest
Chrisette MicheleSelf - Musical Guest
Bill ClintonSelf - Guest
Paul RuddSelf - Guest
Tony DungySelf - Guest- Cole HamelsSelf - Top Ten Presenter
Ashley OlsenSelf - Guest
John LegendSelf - Musical Guest
DuffySelf - Musical Guest
Robin WilliamsSelf - Guest
Shannen DohertySelf - Guest
Emma WatsonSelf - Guest
Queen LatifahSelf - Guest
Jennifer GarnerSelf - Guest
Elon MuskSelf - Guest
Samuel L. JacksonSelf - Guest
Emeril LagasseSelf - Guest
Iggy PopSelf - Musical Guest- Fatboy SlimSelf - Musical Guest
Jessica SimpsonSelf - Guest
Meg RyanSelf - Guest
Barack ObamaSelf - Guest
LeBron JamesSelf - Guest
Renée ZellwegerSelf - Guest
Gary Mule DeerSelf - Guest
Britney SpearsSelf - Top Ten Presenter
Diane KrugerSelf - Guest- Billy CurringtonSelf - Musical Guest
Steve EarleSelf - Musical Guest
Hayden PanettiereSelf - Guest
John MalkovichSelf - Guest
Serena WilliamsSelf - Guest- Conor OberstSelf - Musical Guest
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