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Cast
Mark RuffaloDominick Birdsey / Thomas Birdsey
Melissa LeoConcettina Ipolita Tempesta 'Ma' Birdsey
Rosie O'DonnellLisa Sheffer
Archie PanjabiDr. Patel
Kathryn HahnDessa Constantine
John ProcaccinoRay Birdsey
Rob HuebelLeo
Michael GreyeyesRalph Drinkwater
Gabe FazioShawn Tudesco / Dominick and Thomas Acting Double
Harris YulinFather Lavie
Bruce GreenwoodDr. Hume
Marcello FonteDomenico Onofrio Tempesta
Sue Jean KimDr. Yup
Michael Simon HallStuart Feinstein
Gina CostiganMrs. O'Meara
Steven CoxBoyfriend of Dr. Hume's Daughter
MorningStar AngelineNabby Drinkwater's Wife- Al LineaAbruzzi
Show all 79 cast members
- Richard FitchMill Foreman
Amy Lynn StewartMerciful Mother
Guillermo DíazSergeant Mercado
Marylouise BurkeLibrarian
Brian GoodmanAl
Sandra BerriosSocial Worker at Hatch
Laura SilvermanKristin
Christine ParksHumanities Department Chair- Morgan SullivanOffice Buddy
Jake RobardsLandlubbers (voice)
Michael GenetThomas' Surgeon- María GonzalezMa's Oncology Nurse
A.C. PetersonGene Diogenes
Christopher J. HankeThad
James QuattrochiBus Driver- Rachel B. JoyceJeanette
- Paul ColemanSupport Group Counselor
Brandon J. DirdenKyle's Dad
Katt MastersonDoreen
Jason FurlaniLarry Penn- Annie FitzgeraldMiss Hanker
Kate GrimesEnglish Professor- Acahkos JohnsonPenny Ann Drinkwater
Joseph RagnoHenrey Rood, Henrey Hood
Jaiden KleinMarie Sexton
Charlie ReinaChanny- Violet AdamsBunny Borsa
- Oliver PatnodeOtero
Chelsea SheetsBrunette
Matt HelmYoung Leo
Felix SolisNurse
Laura EstermanRuth Hood
Joe GrifasiSteve Falice
Derek Goh17-19 Year Old Dominick & Thomas Acting Double
Raymond Neil HernandezOmar
Simone CoppoVincenzo Tempesta
Sean CullenDr. Yates
Federico DordeiNunzio Tucci
Agatha NowickiAngie Constantine
Rocco MasihiYoung Thomas Birdsey
Irene MuscaraProsperina Tucci- Adrienne R. WilliamsMrs. Birdsall
Shannon PlumbCharlotte
Tatanka MeansNabby Drinkwater
Donnie MasihiYoung Dominick Birdsey- Zaria Degenhardt11 Year Old Concettina
- Mark A. GammaMourner Mark
Wayne J. MillerMourner Wayne
Thomas Gionet-LavigneRay's Orderly- Alexander HackerTempleton
- Robert MladinichPaddy Wagon Officer
Philip EttingerEarly Adulthood Dominick Birdsey / Thomas Birdsey
Aisling FranciosiYoung Dessa Constantine
Destry Allyn SpielbergDr. Hume's Daughter
Imogen PootsJoy Hanks
Roberta RiganòIgnazia Tempesta
Juliette LewisNedra Frank- Tim RuddyRobocop
Ethan CrystalThin Sailor- James PravasilisThird Guard
- Michael Armand DeMatteoFatso
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